_341_ _Objectives: _In patients with multivessel disease both the detection of the culprit lesion and the exact allocation are important preconditions for sufficient treatment and improved outcome. In a vessel based approach the combination of quantitative coronary angiography and fractional flow reserve measured by a pressure wire should be advantageous compared to myocardial SPECT, as morphological and functional information is delivered simultaneously. Therefore our aim was to evaluate MS in the detection and allocation of hemodynamically significant stenoses obtained by the (...) combined gold standard QCA plus FFR in patients with multivessel disease. _Methods: _FFR and QCA of 95 vessels in 80 patients have been evaluated. Hemodynamically significant target lesions were defined as intermediate stenoses between 50 and 75% with an FFR. (shrink)

This is a study of Frege's permutation argument in Part I, Section 10, of Frege's Basic Laws of Arithmetic.

This paper explores the relationship between mania, or pathologically elevated mood, and philosophical theories of well-being. A patient, Mr. M., is described who oscillated between periods when he refused medication and periods when he was willing to accept it, and whose desires and life objectives were radically different in his medicated and unmedicated states. The practical dilemmas this raised are explored in terms of the three principal philosophical theories of well-being: hedonism, the desire fulfillment theory, and objectivism. None of these (...) adequately accounted for Mr. M.'s case: hedonism, because pleasure is increased in mildly manic states; desire fulfillment theories, because these suggest that an unending cycle of treatment and nontreatment would be in Mr. M.'s best interests; and objectivism, because, in a form that would be applicable to Mr. M., that theory brings with it substantial risks of paternalism. Four further philosophical approaches are explored briefly—approaches focusing on autonomy, rationality, personal identity, and illness, respectively—but these also provide no straightforward resolution of the clinical dilemmas. It is concluded that philosophical analysis, even if it does not resolve cases like Mr. M.'s, can deepen our understanding of the issues involved in clinical decision making in psychiatry, especially the importance of sensitivity to the patient's wishes and values; and conversely, that mild mania is an important "real life" case against which philosophical theories of well-being can be tested. (shrink)

A review of A.W. Moore's book on Kantian themes in religion and ethics. -/- .

Peter Abelard (1079–1142 ce) was the most wide‐ranging philosopher of the twelfth century. He quickly established himself as a leading teacher of logic in and near Paris shortly after 1100. After his affair with Heloise, and his subsequent castration, Abelard became a monk, but he returned to teaching in the Paris schools until 1140, when his work was condemned by a Church Council at Sens. His logical writings were based around discussion of the “Old Logic”: Porphyry's Isagoge, aristotle'S Categories and (...) On Interpretation and boethius'S textbook on topical inference. They comprise a freestanding Dialectica (“Logic”; probably c.1116), a set of commentaries (known as the Logica [Ingredientibus], c. 1119) and a later (c. 1125) commentary on the Isagoge (Logica Nostrorum Petititoni Sociorum or Glossulae). In a work Abelard called his Theologia, issued in three main versions (between 1120 and c.1134), he attempted a logical analysis of trinitarian relations and explored the philosophical problems surrounding God's claims to omnipotence and omniscience. The Collationes (“Debates,” also known as “Dialogue between a Christian, a Philosopher and a Jew”; probably c.1130) present a rational investigation into the nature of the highest good, in which the Christian and the Philosopher (who seems to be modeled on a philosopher of pagan antiquity) are remarkably in agreement. The unfinished Scito teipsum (“Know thyself,” also known as the “Ethics”; c.1138) analyses moral action. (shrink)

What is the function of cognition? On one influential account, cognition evolved to co-ordinate behaviour with environmental change or complexity. Liberal interpretations of this view ascribe cognition to an extraordinarily broad set of biological systems—even bacteria, which modulate their activity in response to salient external cues, would seem to qualify as cognitive agents. However, equating cognition with adaptive flexibility per se glosses over important distinctions in the way biological organisms deal with environmental complexity. Drawing on contemporary advances in theoretical biology (...) and computational neuroscience, we cash these distinctions out in terms of different kinds of generative models, and the representational and uncertainty-resolving capacities they afford. This analysis leads us to propose a formal criterion for delineating cognition from other, more pervasive forms of adaptive plasticity. On this view, biological cognition is rooted in a particular kind of functional organisation; namely, that which enables the agent to detach from the present and engage in counterfactual inference. (shrink)

Sense of agency refers to the sense of initiating and controlling actions in order to influence events in the outside world. Recently, a distinction between implicit and explicit aspects of sense of agency has been proposed, analogous to distinctions found in other areas of cognition, notably learning. However, there is yet no strong evidence supporting separable implicit and explicit components of sense of agency. The so-called ‘Perruchet paradigm’ offers one of the few convincing demonstrations of separable implicit and explicit learning (...) systems. We adopted this approach to evaluate the implicit–explicit distinction in the context of a simple task in which outcomes were probabilistically caused by actions. In line with our initial predictions, we found evidence of a dissociation. We discuss the implications of this result for theories of sense of agency. (shrink)

Detailed studies of people who have experienced the Capgras delusion (the delusion that certain other people, usually close relatives, have been replaced by impostors) have led to advances in constructing an account which can deal with the basic symptomatology, testing alternative possibilities, generating and testing non‐trivial predictions, and broadening the scope of the basic account to encompass other delusions. This paper outlines these developments. It uses them to explore implications for understanding the formation and maintenance of beliefs, and to discuss (...) basic principles of what has come to be known as cognitive neuropsychiatry. (shrink)

'superb' -Tom Stoneham, Oxford MagazineA. W. Moore argues in this bold and unusual book that it is possible to think about the world from no point of view. His argument involves discussion of a very wide range of fundamental philosophical issues, including the nature of persons, the subject-matter of mathematics, realism and anti-realism, value, the inexpressible, and God. The result is a powerful critique of our own finitude. 'imaginative, original, and ambitious' Robert Brandom, Times Literary Supplement.

In lieu of an abstract, here is a brief excerpt of the content:Philosophy, Psychiatry, & Psychology 9.1 (2002) 55-59 [Access article in PDF] One Stage Is Not Enough Andrew W. Young and Karel W. de Pauw Keywords: delusions, Cotard delusion, Capgras delusion, cognitive neuropsychiatry. WE WELCOME THE OPPORTUNITY to offer our reflections on Philip Gerrans' interesting paper. Our opinion is that on fundamental issues we agree quite a bit—but there are clear differences when it comes to details.The most basic (...) issue concerns the nature of the enterprise. Like Gerrans, we think that it is possible to create testable accounts of the formation and maintenance of what would otherwise seem bizarre and inexplicable delusions, and that these accounts should be grounded in theoretical models of factors that underpin our everyday perception and reasoning. This general approach certainly forms part of what has been called cognitive neuropsychiatry. However, we disagree with Gerrans in that we see cognitive neuropsychiatry as an attempt to draw on the underlying logic of cognitive neuropsychology, rather than (as Gerrans implies) its current methods. The underlying logic of cognitive neuropsychological approaches has been to try to understand the effects of brain injury in terms of disruption of different components of theoretical models of normal abilities. In this approach, a model of normal performance is tested by its ability to account for the effects of brain injury. Where the model of normal performance also provides a convincing account of brain injury it is retained, and when it fails to account for effects of brain injury, it is revised or abandoned. In cognitive neuropsychiatry, the key theoretical move has been to argue that an adequate model of normal performance should be able to account for any disordered pattern (Ellis and Young 1990). The same logic of seeking to explain disordered performance by reference to models of normal function is then attempted, but for disorders that would usually fall within the province of psychiatry.In our opinion, however, cognitive neuropsychiatry will not simply involve importing the methods of cognitive neuropsychology into the new domain; they will need to be developed and adapted to fit the new agenda (Young 2000).In cognitive neuropsychology, progress has often come from the careful investigation of people with stable, selective deficits of fundamental cognitive functions involved in sensory analysis, memory, and verbal or motor output. In contrast, delusional beliefs can be relatively unstable; often they are only held for a few weeks or even days. When the delusions change, patients may modify or abandon them as suddenly as they seemed to form them, or they may give them up much more slowly and reluctantly. At the very least, this creates difficulties in the timing of investigations and in interpreting the relation of deficits and symptoms, which may be recorded on separate dates. These methodological problems [End Page 55] are exacerbated by the fact that deficits linked to complex abnormal experiences such as delusions may be multifaceted and diffuse, even when the delusions themselves have a specific content or theme. Such complications do not invalidate cognitive neuropsychiatry, but they do mean it will need to develop its own methods for dealing with them and making appropriate inferences.One of the key complexities that has surfaced already involves the idea that delusional beliefs might reflect the interaction of two or more contributory factors. Gerrans discusses a particular variant of this idea, which had been suggested by Young and Leafhead (1996) as an approach to understanding the Cotard delusion: The Cotard delusion represents a depressed person's attempt to account for abnormal perceptual experiences. It follows that the delusion is based on an unfortunate interaction between different contributory factors. One set of factors creates the abnormal perceptual experiences, which are characterised by lack of emotional responses and feelings of emptiness, depersonalisation and derealisation. The other factors result in a misinterpretation of these perceptual changes, in which the patients' depressed moods lead them correctly to attribute the changes to themselves, but to exaggerate their consequences. (Young and Leafhead, 1996, 166) Gerrans describes this as a two-stage account, but argues that a one-stage account based only on abnormal perceptual... (shrink)

This article aims to supplement our understanding of later developments within European universities, that is, Scholastic thought, by attending to how certain pre-Scholastics, namely, Peter Abelard and other twelfth-century philosophers, thought about artifacts and social constructions more generally. It focuses on the treatment of artifacts that can be cobbled together out of Abelard’s Dialectica. The article argues that Abelard attempts to sharply distinguish the world of things from the world of human-made objects. This is most apparent in his treatment of (...) creation and human acts of making. Yet there are places in his thought where we see some hesitancy. Many of Abelard’s peers seem to have drawn on the reasons why Abelard hesitates, and they blur the line between human-made objects such as houses and substances such as rocks and humans. Others seem to go further than Abelard—perhaps inspired by some of the thoughts that Abelard also entertains about social constructions such as days and speeches—and assert that even houses are merely convenient fictions. (shrink)

Majority-Minority electoral districts, while increasing the number of minorities in legislatures, work to deepen divisions among racial groups, to exacerbate the systematic disadvantages of some individuals, and to impede effective representation. I examine another form of race-conscious districting that will increase marginalized minority presence in legislatures while avoiding these problems.

In his influential book Truth, Paul Horwich deploys a philosophical method focused on linguistic usage, that is, on the function(s) the concept of truth serves in actual discourse. In doing so Horwich eschews abstract metaphysics, arguing that metaphysical or ontological conceptions of truth rest on basic misconceptions. From this description, one might reasonably expect Horwich's book to have drawn inspiration from, or even embodied philosophical pragmatism of some kind. Unfortunately Horwich relies upon Russell's tired caricature of pragmatism about truth (''p' (...) is true if and only if it is useful to believe p' (Ibid., p. 34, p. 47)), and as a result underestimates the challenge it poses to Minimalism. This paper develops a pragmatist critique of minimalism that focuses on the seemingly central, plausibly constitutive role played by the concept of truth in the speech-act of assertion. The critique suggests that Horwich's Minimalism does not and cannot accomplish its stated goal of explaining all of the facts involving truth. Indeed, the kind of thorough-going deflationism sought by Horwich and others (including pragmatist sympathizer Bob Brandom) is incompatible with an adequate account of assertion, and perhaps other concepts (like belief, judgement and inquiry) as well. (shrink)

Anne Conway (1631–1679) is sometimes said to be a Monist. I present several kinds of Monism and then investigate whether any of these adequately capture Conway’s theory of substance and individuals. I outline Conway’s reasons for postulating that there are three irreducibly distinct kinds of essence or substance, which by itself demonstrates that she is not an unrestricted Token Monist. I then examine her various remarks about created substance, which she sometimes refers to as “a creature” and other times as (...) “creatures.” Here I argue that, while the texts are ambiguous, there are compelling reasons—especially given her views about salvation and justice—to believe that she is merely a Type Monist at the level of created substances. I then examine two theses that result from her relativized Type Monism. First, there are no substantial barriers between, say, horses and humans, and thus all created things can convert into one another as they improve or regress morally. Second, there is no substantial difference between minds and bodies. I suggest that Conway’s arguments against Descartes’ Type Pluralism could easily be included as part of a more inclusive philosophy syllabus. (shrink)

The God of Israel in the theology of Robert Jenson -- Jenson's hermeneutics -- Godd in Israel's life -- The God of Israel and Jesus -- The God of Israel and the Trinity -- The God of Israel, the People of God, and the Eschaton -- The identity of the one and triune God of Israel -- Jenson, the God of Israel, and non-supersessionist theology.

Many philosophers who support a four-dimensionalist metaphysics of things also conceive of experience as a state of a mind having temporal extension or existing as a momentary feature of the dimension of time. This essay shows that such a strict four-dimensionalism — suggested in works by D. M. Armstrong, Mark Heller, and David Lewis — cannot be correct, since it cannot allow for the passing of time that is essential to awareness. The argument demonstrates that the positing of any temporal (...) process at all must compromise the strict four-dimensionalist view of the temporality of experience. This is not to say that the traditional endurantist view is left wholeheartedly endorsed. As I point out, this traditional view makes several questionable claims of its own that must be carefully scrutinized. Still, the criticism of the strict four-dimensionalist ontology indicates a direction to be followed in developing a successful metaphysics of experience. (shrink)

This study focuses on concepts and, ultimately, their possible implementation in brains. Especially salient is analysis of Jerry Fodor's work. The view of concepts found therein is one where many of both are "simple": to be ascribed or to token most concepts doesn't require being ascribed or tokening any other concepts, and most symbols lack "parts" which are themselves symbols. This is, I think, a very popular, and mistaken, view. ;In chapter 1, I argue that Fodor's theory of content is, (...) contra its goals, neither naturalistic nor atomistic. A deep mistake undermines both, viz. that there's no way to individuate a mental symbol non-semantically. This leads to chapter 2, where I explore the much neglected notion of Mentalese syntax. I argue that there are three possible principles of syntactic type individuation, and that these turn out not only to be incompatible but also inadequate for a "language of thought." I conclude that the idea of simple mental symbols is in trouble. ;This then allows me to argue in chapter 3 that we don't have to fear intentional holism , which sanctions the prevalence of complex concepts. I next sketch, in chapter 4, the sort of complex symbols needed to implement complex concepts. The chapter's bulk consists in an empirical argument for the complexity view via seven domains of current cognitive science, including concept context dependency, typicality effects, association, and reasoning. ;Chapter 5 concludes by exploring connectionism. I argue that, despite problems, connectionism seems on the right track in a way that Fodor's computationalism isn't. For example, it's more explicitly brain-like; in dropping the idea of mental computation over symbols it's free from the syntax problems of chapter 2; and, most important, it's highly compatible with the complexity view, which best characterized the cognitive processes of chapter 4. (shrink)

This essay argues against David Carr’s relativism by clarifying the in principle requirements appropriate to non-relative truths and showing that de facto differences of conceptual frameworks threaten none of them. Non-relative truths are not threatened by history. This defense of non-relative truth belongs to a larger defense of Husserlian “science” that shows how essences, even those “delivered” by history, have a universal “governance” and can be affirmed in nonrelative truths-as such science requires. If history also allows the other qualities of (...) Husserlian science to obtain, then, the essay concludes, such science can exist even as a “situated science.”. (shrink)

In Act 1 scene iv of Macbeth, Duncan reflects that: 'There's no art to find the mind's construction in the face'. In contrast, the claim that Andy Young sets out in this book is that we are now developing a science of face perception which can indeed shed light on certain aspects of mentallife. Face and Mind consists of a series of seminal research and review papers on face perception published by the author and his colleagues over the last 12 (...) years. A comprehensive introductory chapter, written especially for this volume, serves to draw together the various themes explored in thedifferent contributions. The book examines the question of how faces are special, in terms of their social, biological, and theoretical roles. In particular, Face and Mind seeks to determine what our understanding of the face can tell us about the human brain. It discusses the evidence for anevolved neural substrate for face perception, and the question of whether we are innately predisposed to recognise faces, to find them attractive, and to decode the many social signals they give us. The ability of the human brain to process and remember the many different faces that we see andsubsequently recall is analysed. Young includes detailed studies of the types of impairment to face perception which can follow brain injury or psychiatric illness, and uses them to address these questions, as well as other issues of high intrinsic and interdisciplinary interest. These include theextent to which our mental lives result from the operation of discrete components devoted to different purposes, the differences between conscious and non-conscious processes, and how we use evidence to support our beliefs about the world. Because of the huge variety of social signals read from theface, it can offer unique theoretical and philosophical insights into these questions. This fascinating book will be of interest not only to psychologists and neuropsychologists working in the field of visual perception, but to cognitive scientists generally. It provides an excellent summary ofthe most important theorietical and empirical work done on face perception in recent years, and as such will be of interest to advanced undergraduate and post-graduate students in psychology, philosophy, and cognitive science. (shrink)